The 4th Annual Winship Scientific Symposium and poster session was held on Thursday, October 26 and featured research done by members of the WCI scientific programs and core facilities. The poster session offered a great environment for scientists to discuss research, form collaborations and build team science interactions.

Thank you to everyone who presented posters at this year's event. We received excellent response to our call for research posters. Please scroll down to see the posters submitted by the poster session participants.

Brain Tumor Program

1. Synthesis, Radiolabeling and In Vivo Evaluation of Syn-[18]FACBC As A Potential Tumor Imaging Agent
Weiping Yu, A M Giamis, L Williams, E Malveaux, Z Zhang, F Kurosaki, Mark M Goodman

2. Investigation Strategies of Glioblastoma Multiforme: Impact on Clinical Outcomes
Heather G Gatcombe, MD, Jeffrey J Olson, MD, Mourad Tighiouart, PhD, Robert Marcus, MD, Dan Brat, MD, PhD, Hui-Kuo Shu, MD, PhD and Ian Crocker, MD

3. CSCRF/SDF-1 Axis Promotes VEGF-mediated Tumor Angiogenesis Through Akt and MAPK Signaling Pathways
Joann Brooks, Zhongxing Liang, Seungee Kang, Margaret Willard, Ke Liang, Younghyoon Yoon, Amit Maity, Zhuo Chen and Hyunsuk Shim

4. Improved Focal Radiotherapy Treatment of High-Grade Gliomas with Magnetic Resonance Spectroscopy-Aided Target Delineation
Sheila Keilholz, PhD, Tim Fox, PhD, Ian Crocker, MD, Hui-Kuo Shu, MD, PhD, Paul Pantalone, Kathleen Williams

5. Anti-Tumor Activity of a New Class of Small Molecules Selectively Targeting the Hypoxia/HIF Pathway
Vladimir E Belozerov, Taku Narita, Jiyoung Mun, Suazette Reid, Rita De Noronha, Hui Mao, Saroja N Devi, Mark Goodman, Kyriakos C Nicolaou, Ruiwen Zhang, Bing Wang and Erwin Van Meir

6. Hypoxia and Genetic Upregulation of Tissue Factor Expression in Glioblastoma and its Role in !%Pseudopalisading!& Necrosis Development
Yuan Rong, Carol Tucker-Burden, Donald L Durden, Erwin G Van Meir and Daniel J Brat

7. Novel Nanocarriers for Brain Tumor Imaging and Treatment
Abhiruchi Agarwal, Efstathios Karathanasis, David Jaye, Ravi V Bellamkonda

8. Nuclear Localization as a Mechanism for Inhibiting the Tumor Suppressor Properties of PTEN
Gabriela Denning, Bernadette Jean-Joseph, Chenyu Prince, Peter Vogt, Donald L Durden

9. MicroPET Measurement of Delivery to Brain of Brain Cancer Drug Candidates (2ME2, 2FEE2, KCN-1)
Jiyoung Mun, Ronald Voll, Vladimir Belozelov, Seung Hee Kang, Yuefang Wang, John R Votaw, Larry Williams, Erwin Van Meir, Hyunsuk Shim, Paraskevi Giannakakou and Mark M Goodman

10. A Novel p53-Independent Function for p14ARF: The Regulation of Tumor Angiogenesis
Abdessamad Zerrouqi, Beata Pyrzynska, Daniel Brat and Erwin Van Meir

Cancer Drug Discovery, Development and Delivery

11. Establishment of a Rapamycin-Resistant Cell Line that Retains Sensitivity to PI3 Kinase Inhibitors
Xuerong Wang, Ping Yue, Fadlo R Khuri, Shi-Yong Sun

12. Inhibition of NFkB by a Novel Curcumin Analogue
Andrea L Kasinski, Yuhong Du, Shala Thomas, Aiming Sun, James P Snyder, Dennis Liotta and Haian Fu

13. KLF5 Interacts w/ P53 in Regulating Survivin Expression in Acute Lymphoblastic Leukemia
Ningxi Zhu and Muxiang Xhou

14. Development of Novel Small Molecule Inhibitors Targeting CXCR4 Against Cancer Metastasis
Zhongxing Liang, Weiqiang Zhan, Younghyoun Yoon, Ghazala Datoo, James Snyder, Dennis Liotta and Hyunsuk Shim

15. Expression of Livin, A Novel Member of the Inhibitor-of-Apoptosis Protein (IAP) Family, in Neuroblastoma: Possible Prognostic Significance
Anindya Dasgupta, Lubing Gu, Carlos S Alvarado, Muxiang Zhou, Harry Findley

16. FGFR3 Activated p90RSK2 to Mediate Hematopoietic Transformation by a Novel Two-Step Mechanism
Sumin Kang, Shaozhong Dong, Ting-lei Gu, Michael S Cohen, Sagar Lonial, Hanna Jean Khoury, D Gary Polakiewicz and Jing Chen

17. b2-Microglobulin Promotes the Growth of thuman Renal Cell Carcinoma Through the Activation of the Protein Kinase A, Cyclic AMP Responsive Element Binding Protein and Vascular Endothelial Growth Factor Axis
Takeo Nomura, Wen-Chin Huang, Haiyen E Zhau, Daqing Wu, Zhuhui Xie, Majd Zayzafoon, Andrew N Young, Fray F Marshall, M Neale Weizmann, Leland W K Chung

18. FTIs Impair Chromosomal Maintenance in Cell Lines and Human Tumors by Compromising CENP-E and !VF Functionality and Disrupting Kinetochore Capture
Schafer-Hales KJ, Iaconelli J, Banks K, Snyder JP, Prussia A, El-Naggar A, Khuri FR, Giannakakou P, Marcus AI

19. Direct Interaction of Histone Deacetylase-6 with HIF-1 Alpha Regulates Survivin Gene Transcription Independent from its Deacetylase Activity
Prasanthi Karna, Zehong Cao and Lily Yang

20. The NSCLC Tumor Supressor LKB1 Functions in Actin-Dependent Cancer Cell Motility
Shumin Zhang, Katherine Hales, Xhazia ali, Walter Smith, Wei Zhou, Paula Vertino, Adam Marcus

21. 14-3-3 Functions as a General Integrator of Pro-Survival Signals in Hematopoietic Transformation by Diverse Leukemogenic Fusion/Mutant Tyrosine Kinases
Shaozhong Dong, Sumin Kang, Tinglei, Gu, Sean Kardar, Sagar Lonial, Hanna Jean Khoury, Fadlo Khuri, Haian Fu and Jing Chen

22. MAPK36 Regulates ASKa Through a 14-3-3-Mediated Ternary Complex
Lisa M Cockrell, Erinn H Goldman and Haian Fu

Cancer Control and Population Sciences

23. The Role of Patient Adherence in Maintenance of Results After Lymphedema Therapy
Peter Johnstone, MD, FACR, Kennedy Hawkings, OTR/L, CLT, Stephanie Hood, MPT, CDT

24. Bcl-2, Bax, Bak Levels in Colon Crypts and Colon Cancer Risk Factors in the Markers of Adenomatous Polyps II Case-Control Study
Veronkia Fedirko, Carrie R Daniel, Roberd M Bostick

25. TGFalpha and TGFbeta1 Levels in Colon Crypts, Colon Cancer Risk Factors, and Incident, Sporadic Colorectal Adenomas in the Markers of Adenomatous Polyps II (MAPII) Case-Control Study
Carrie R Daniel, Roberd M Bostick, Aasma Shaukat-Bhatti, Woodrow J Coker II, Jay Mizzell, Marianna Toma-Drane, Vlerie Kennedy, W Dana Flanders

26. Expression of APC in Normal-Appearing Rectal Mucosa Differs Between Those With and Without Incident, Sporadic Colorectal Adenomatous Polyps and May be Modulated by Diet: Results From the Markers of Adenomatous Polyps II (MAPII) Case-Control Study
Aasma Shaukat, Chiranjeev Dash, Carrie R Daniel, Vaunity Cohen and Roberd M Bostick

27. Enhanced Psychosocial Stress-Induced IL-6 Responses are Associated with Attenuated Stress-Induced Cortisol Responses in Patients with Major Depression and Increased Early Life Stress
TWW Pace, O Alagbe, TM Mietzko, CB Nemeroff, DL Musselman, CM Heim and AH Miller

28. Induction of MAPK-p38 After the First Injection of Interferon Q Predicts Severity of Interferon-alpha-Induced Depressive Symptoms in Patients with Hepatitis C Infection
Oyetunde Alagbe, MD, Hitoshi Takahashi, MD, Zhang Jinrong, MD, Fang Hu, MD, PhD, Thaddeus Pace, PhD, Breanne Massung, Leonie Welberg, PhD, Bobbie Woolwine, MSW, Andrew Miller, MD, Charles Raison, MD

29. Cilomilast, a Phosphodiesterase Type 4 Inhibitor, Increases Glucocorticoid Receptor Function through Activation of Protein Kinase A Pathways
Fang Hu, Gerald J Vogt, Jinrong Zhang, Andrew H Miller

30. Paroxetine for the Prevention of Depression in Patient Receiving Interferon-alpha Plus Ribavirin for Hepatitis C
Charles L Raison, MD, Bobbi J Woolwine, MSW, John M Zajecka, MD, Dwight L Evans, MD, Gregory M Asnis, MD, Andrew H Miller, MD

31. Expression of TGFalpha1 in Normal-Appearing Rectal Mucosa in Individuals with and without Sporadic Colorectal Adenomatous Polyps
Amparo G Gonzalez-Feliciano, Chiranjeev Dash, MD, MPH, Veronika Fedirko, MPH, Aasma Shaukat-Btatti, MD, MPH, Carri R Daniel, MPH, Roberd M Bostick, MD, MPH

32. A Relationship Between the Neuroendocrine Response and CSF HVA Concentrations to Depressive-Like Behavioral Alterations During INF alpha Administration in Rhesus Monkeys
Felger JC, Knowlson KE, Alagbe O, Mook D, Sanchez MM, Nemeroff CB and Miller AH

Cancer Genomic and Genetic Instability

33. DNA Damage Induced ROS Response in Saccharomyces cerevisiae
Lori Rowe, Myfawyny Hopkins and Paul Doetsch

34. Rapid Screening Tool for Cytotoxic DNA Damaging Agetns and Radiation Sensitization
Charles L Perkins, MD, PhD, and Paul W Doetsch, PhD

35. Transcriptional Mutagenesis: New Insights into DNA Repair Pathways
Cheryl L Clauson, Bernard Weiss, MD, Paul W Doetsch, PhD

36. Prediction of Aberrant CpG Island Methylation in Cancer
McCabe MT, Lee EK and Vertino PV

37. Development and Optimization of a High Throughput Kinetic Assay for BRCA1 Associated Protein 1 (MAP1)
Kenneth Friedrich, Yuhong Du, Blossom Sneed, Raymond Dingledine, Haian Fu and Keith Wilkinson

39. Characterization of Nup98/DDX10, a chimeric protein associated with Acute Myelogenous Leukemia. Songli Xu and Maureen A. Powers

Prostate Cancer

39. Salvage Reostatectomy for Prostate Cancer: Data from the Surveillance Epidemiology & End Results Registry
Peter Johnstone, MD, FACR, Michael Goodman, MD, Kevin C Ward, Vasily Assikis, MD, Kenneth Ogan, MD

40. Initial Experience with the PET Radiotracer Anti-1-Amino-3-[18F]fluorocyclobutane-1-carboxylic acid (anti[18F]FACBC) in Newly Diagnosed Prostate Cancer
David M Shuster, MD, John R Votaw, PhD, Weiping Yu, PhD, PT Nieh, MD, Jonathan A Nye, PhD, Viraj Master, MD, PhD, Raghuveer K Halkar, MD, Muta M Issa, MD, Fray F Marshall, MD, Mark M Goodman, PhD

41. Human Prostate Cancer Interaction with Bone-Specific Microenvironment Promotes Epithelial-Mesenchymal Transition and Increased Bone Metastatic Potential
Valerie A Odero-Marah, Jianchun Xu, Rebecca S Arold, Yun Xing, Leland W K Chung and Haiyen E Zhaun

42. Honokiol, A Natural Product from Plan, Inhibits the Bone Metastatic Growth of Human Prostate Cancer Cells
Katsumi Shigemura, Jack L Arbiser, Shi-Yong Sun, Majd Zayzafoon, Peter A S Johnstone, Babette Weksler, Haiyen E Zhau and Leland WK Chung

43. Association of a Homozygous 2-bp Deletion in snoRNA U50 with Human Prostate Cancer
Xue-Yuan Dong, Peng Guo, Xiaodong Sun, Wei Zhou, John Petros, Qunna Li, Robert L Vessella, Adam S Kibel, Jin-Tang Dong

44. Beta2 Microglobulin as a Regulator of Androgen Receptor and Survival in Prostate Cancer Cells
Jonathan Havel and Wen-Chin Huang

45. A Moderately Low Phosphate Diet Reduces Tumor Burden in a mouse Model of Skin Tumorigenesis
Corinne E Camalier, George R Beck, Jr., Nancy R Colburn, Matthew R Young, Christine Perella

46. Hormonal and Developmental Regulation of Micro-RNA's in Prostate Cancer Cells
Colleen D McCabe, Adam Beauchamp, Suresh Karanam, Carlos Moreno

47. Rap1: A Link Between Hypoxia, Prostate Cancer Progression and Metastasis
Veronica Henderson, Mohamed Ali-Seyed, Hitoshi Kitayama, Marie Csete, Pengbo Liu, Carlos S Moreno

48. Pro-proliferative Transcription Factor KLF5 is a Cofactor Mediating TGFb's inhibitory Function in Epithelial Cells
Peng Guo, Xue-Yuan Dong, Xiaohui Zhang, Xiaodong Sun, Jin-Tang Dong

49. ADAM9 Plays an Important Role in Prostate Cancer Survival and Responds Differently to Different Reactive Oxygen Species Mediated Cell Kill
Shian-Ying Sung and Sajni Josson

50. Soluble METCAM/MUC18 Blocks Tumor-Angiogenesis and Tumorigenesis of Human Prostate Cancer LNCaP Cells
Guang-Jer Wu and Eugene L Son

51. VEGF Autocrine Signaling is a Survival Pathway in Bone-Metastatic Human Prostate Cancer Cells
Shareen Iqbal, Seong Il Seo, Haiyen Zhau, Leland Chung, Daqing Wu

Breast Cancer Program

52. Deletion, Mutation and Decreased Expression of ATBF1 in Human Breast Cancer
Xiaodong Sun, Yingfa Zhou, Kristen B Otto, Mingrong Wang, Ceshi Chen, Wei Zhou, Krithika Subramanian, Paula M Vertino, Jin-Tang Dong

53. Recepto-Targeted Magnetic Iron Oxide Nanoparticles for In Vivo MRI of Breast Cancer
Xiang-Hong Peng, Andrew Wang, Xiaoxia Wang, Chunchun Ni, William C Wood, Shuming Nie, Hui Mao and Lily Yang

54. Simultaneous and Quantitative Detection of Multiple Biomarkers in Human Breast Cancers Using Semiconductor Multicolor Quantum Dots
Maksym V Yezhelyev, Ahmad Al-Hajj, Tonqrui Liu, TJ Philip, Revaz Machaidze and Ruth M O!&Regan

55. Restoration of Tamoxifen Sensitivity in ER-negative Breast Cancer Cells: Tamoxifen-bound Reactivated Estrogen Receptor Recruits Distinct Chromatin Modifying Corepressor Complexes
Neeraj K Saxena and Dipali Sharma

56. Modulation of Distinct Co-Regulator Proteins Contribute to Tamoxifen Resistance
Neeraj K Saxena and Dipali Sharma

57. Inhibition of mTOR Pathway Enhances Sensitivity of Breast Cancer Triple Negative Cell Lines to Erlotinib
T Liu, MV Yezhelyev, X Zhang, Y He, A Al-Hajj, R Machaidze, T Philip, RM O'Regan

58. Computational Methods for the Study of Tomogrpahic Breast Imaging
Ioannis Sechopoulos, Sankararaman Suryanarayanan, Srinivasan Vedantham, Carl D'Orsi, Andrew Karellas

59. Galectin-3 Modulates Nitric Oxide-Induced Adhesion and Migration of Breast Cancer Cells
Brandi C Brandon, Tanja L Caldwell and Gary L Sanford

Aerodigestive and Lung Cancer

60. The Akt Inhibitor, Perifoxine, Induces Growth Arrest & Apoptosis of Human Lung Cancer Cells Involving Cox-2 Activation
Heath Acuff Elrod, Xiangguo Liu, Ping Yue, Fadlo R Khuri, Shi-Yong Sun

61. PPARfx Ligands Induce Death Receptor 5 (DR5) Expression and Distribution on Cell Surface and Enhance TRAIL-Induced Apoptosis in Human Lung Cancer Cells
Wei Zhou, Xiangguo Liu, ping Yue, Fadlo R Khuri, Shi-Yong Sun

62. Synergistic Tumor Growth Inhibition by Combined Treatment with Green Tea Epigallocatechin-3-gallate (EGCG) and an Epidermal Growth Factor Receptor (EGFR)  Tyrosine Kinase Inhibitor (TKI) Tarceva in Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Xin Zhang, John E Lee, Mourad Tighiouart, Hyung J Shin, Fadlo R Khuri, Zhuo (Georgia) Chen and Dong M Shin

63. Respiratory Motion in Gastrointestinal Cancer: Implications for IMRT and Stereotactic Body Radiosurgery
Charles L Perkins, MD, PhD, Tim Fox, PhD, Eric Elder, PhD, David Kooby, MD, Charles Staley, MD and Jerome Landry, MD

64. Antitumor Effects of Combined Bortezomib and Tipifarnib in Head and Neck Squamous Cell Carcinoma (HNSCC) Cells
Carmen M Kalss, Zhuo (Georgia ) Chen, Xin Zhang, John Lee, Sagar Lonial, Fadlo R Khuri and Dong M Shin

65. The Role of Caveolin-1 in Lymph Node Metastasis of the Head and Neck Cancer
Hongzheng Zhang, Ling Su, Hyung Jun C Shin, Susan Muller, Mourad Tighiouart, Zhiheng Xu, Xin Zhang, Jennifer Hunt, Dong M Shin and Zhuo (Georgia) Chen

66. LKB1 Mutation in Large Cell Carcinoma of the Lung
Diansheng Zhong, Lizheng Guo, Itziar de Aguirre, Xiuju Liu, Neil Lamb, Shiyong Sung, Anthony Gal, Paula M Vertino and Wei Zhou

67. FLIP Downregulation and Its Impact on Celecoxib-induced Apoptosis in Human Lung Cancer Cells
Xiangguo Liu, Ping Yue, Fadlo R Khuri, Shi-Yong Sun

68. Decreased Human METCAM/MUC18 Expression Correlates with the Appearance, but Its Increased Expression Correlates with the Metastasis of Nasopharyngeal Carcinomas
Guang-Jer Wu, Cheng-Feng Frank Chiang, Jin-Ching Lin, Wen-Yi Wang, Shur-Wern Chris Wang and Po-Cheung Kwan

Other

69. Inhibition of Aurora Kinases Overcomes Resistance to Paclitaxel in Ovarian Cancer
Christopher D Scharer, John F McDonald, Benedict B Benigno and Carlos S Moreno

70. SOX4 Participates in an Epidermal Growth Factor Receptor Positive Feedback Loop
Mohamed Ali-Seyed, Christopher D Scharer and Carlos S Moreno

71. Establish a Xenograft Model of Hepatic Human Uveal Melanoma Micometastasis
Hua Yang and Hans E Grossnicklaus

72. Development of a High Throughput Assay for Tumor Heat Shock Protein 90
Yuhong Du, Kamalika Moulick, Haian Fu, Gabriela Chiosis

73. Donor DC Subsets Express Different Co-Stimulators and Influence T-cell Expansion and Survival in Allogeneic Bone Marrow Transplant
Lauren Southerland, Jian-Ming Li and Edmund Waller

74. Frequent and Over-Expression of METCAM/MUC18 IN Human Ovarian Cancer Tissues Implicates Its Positive Role in the Progression of Clinical Ovarian Cancers
Guang-Jer Wu, Eugene L Son, Erin Dickerson, Cynthia Cohen, Mei-Whey H Wu and John McDonald

75. Homeostatic Expansion of Donor FoxP3+CD25+CD4+ Cells in Recipients of CD4+ Cells Depleted Allogeneic Hematopoietic Graft
Mohammed S Hossain, Cynthia R Giver and Edmund K Waller

76. Bioconjugated SERS Tags for Cancer Biomarker Detection on Cell Surfaces
Dominic Ansari, XM Qian and Shuming Nie

77. Apoptotic Donor Leukocytes Limit Mixed-Chimerism Induced by CD40-CD154 Blockade in Allogeneic Bone Marrow Transplantation
Jian-Ming Li, John Gorechlad, Cindy Giver, Christian P Larsen and Edmund K Waller